wnol.info November 25 2017


72 major genetic risk factors for breast cancer identified in new study

November 25 2017, 07:42 | Rex Rios

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Breast cancer is the second most common cancer among women in the USA -affecting one in every eight-but researchers recently found a difference between breast tissue of healthy women versus those with breast cancer that could lead to new kinds of treatment.

The world's biggest genetic study of breast cancer has discovered 72 gene mutations that put women at higher risk and could become targets for treatment.

Professor Chenevix-Trench said a greater understanding of a particular woman's risk of developing breast cancer could help to change the age at which she was offered mammogram screening.

Male breast cancer is usually hereditary and if your family has history with the disease it could increase your risk. It should also help to identify more effectively the women with a high risk of suffering from such a cancer, but also to reduce the screening to be unnecessary and over-diagnosis.

"These findings may inform improved risk prediction, both for the general population and BRCA1 mutation carriers", says Associate Professor Roger Milne at Cancer Council Victoria in Melbourne.

The largest study of breast cancer genes ever done has found 180 separate mutations. When the researchers took a closer look at these, they found distinct patterns specific to breast cancer.

With what the medical community already knows about BRCA1, BRCA2, other variants, plus the newly identified genes, it's estimated that about 39 percent of heritable ER-positive breast cancer risk can be explained, researchers said.

However most of the new variants found were in gene-regulating regions. "Her insurance company might not cover her for breast cancer".

U.S. co-author Professor Peter Kraft, from the Harvard TH Chan School of Public Health, said the findings revealed a wealth of new information about the genetic mechanisms underlying the disease.

October has been recognized as Breast Cancer Awareness Month after the Board of Lewis County Commissioners issued a proclamation on Monday.

Others, known as oestrogen-receptor negative, are not affected by the hormone and are more hard to treat.

"But there are other risk factors". QIMR Berghofer senior researcher Jonathan Beesley said researchers now knew much more about the genetic mechanisms that might cause breast cancer.

Professor John Bridgewater, an oncologist at University College London Hospital, who was not involved in the study, said: 'Many patients will often go on special diets, rather than having conventional treatment.

A further seven genes were identified specifically in association with breast cancers that lacked oestrogen receptors, which don't tend to respond to hormone based therapies.



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