White House officials said the president had invited all of the members of his Cabinet, and their spouses, to Camp David for the weekend.
President Donald Trump once said he got $17 million in a hurricane damage insurance payout for his Mar-a-Lago resort in Florida, but an Associated Press investigation couldn't find much evidence of the supposed damage.
Twelve years after Wilma, Mar-a-Lago is inside Florida's mandatory evacuation zones and is closed ahead of Irma.
Reading from prepared remarks, Trump said that "all of America grieves" for those who have already lost their lives from Hurricane Irma, and he urged people in Florida to heed the directions offered by state and local authorities.
Some 6.5 million people, about a third of the state's population, had been ordered to evacuate southern Florida.
On Saturday afternoon, Trump held a meeting with the Cabinet on the potential impact of Hurricane Irma, now heading to Florida. He said he was saying prayers for us.
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Mar-a-Lago itself has survived a number of other deadly hurricanes, as the property was first built by cereal heiress Marjorie Merriweather Post in 1927.
Trump expressed his condolences for the victims of Irma and Harvey, which struck Texas and Louisiana earlier this month, the Hill reported.
"I think nearly every C abinet member called me once a day from the administration just making sure we have all the resources", Scott said on CBS' "Face the Nation" on Sunday.
"This is a storm of absolutely historic destructive potential".
Hurricane Irma crashed through the Turks and Caicos islands on Thursday and is expected to arrive in Florida on Saturday with winds of up to 185 miles per hour. Climate change is also responsible for sea-level rise, which could cause powerful storm surges and flooding that one day devastates some of Trump's real-estate holdings in the US.